External mechanical loading overrules cell-cell mechanical communication in sprouting angiogenesis during early bone regeneration
Fig 5
Predicted OVSCs organization under rigid fixation and comparison with experimental data.
(A) Alignment of newly formed collagen fibres (white arrows) in the proximity of the cortex (second harmonic signal, two-photon microscopy) during the initial healing phase. The regions of interest considered in the analysis are identified with dashed lines; (B) Percentage distribution of OVSCs orientation for the rigid fixator within the gap and along the periosteum. On the top right, the colour code for cell orientation is reported; (C) Predicted OVSCs self-organization at day 7 for the rigid fixator. On the top right, the colour code for cell orientation is reported.