Modeling cell populations metabolism and competition under maximum power constraints
Fig 5
Coexistence and regime shifts for interacting normal and neoplastic plasma-cells.
Panel (A) shows the time evolution of stock Q1 (in blue) and Q2 (in red hues) according to Eqs 3 and 4 on yearly time scale for configurations defined by the different values of r2 = 1.43·10−2−1.53·10−2h−1 for neoplastic PCs as in Fig 4, and with K = 4.05·1021 ATPeq, r1 = 1.39·10−2h−1, τ1 = τ2 = 72 h, α1 = α2 = 0, Q1(0) = Qss = 0.02·K, Q2(0) = 5·1010 ATPeq. Panel (B) shows the time evolution of stock Q1 (blue) and Q2 (red) for configurations defined by the different values of α1 = c·r1/K and α2 = c·r2/K with c = 0, 1, 2 (solid, dashed, dot dashed lines) and by r2 = 1.47·10−2h−1, r1 = 1.39·10−2h−1, K = 4.05·1021 ATPeq, τ1 = τ2 = 72 h, Q1(0) = Qss = 0.02·K, Q2(0) = 5·1010 ATPeq.