Modeling cell populations metabolism and competition under maximum power constraints
Fig 3
Stable stationary states for normal and neoplastic plasma cells.
Panel (A) shows the actual steady states (colored dots) occupied by the PCs system in the state space defined by the bell-shaped curves P(Q) = r·Q·(1−Q/K) and Jh(Q) = P(Q)/η, depending on the intrinsic growth rates r of normal PCs (r = 1.39·10−2h−1, in blue) and malignant PCs (r = 1.43·10−2h−1−1.53·10−2h−1, red hues), with K = 4.05·1021 ATPeq, τ = 72 h (parameter estimation in Methods). Panel (B) shows the associated stability curve V(Q) defined by dV(Q)/dQ = −dQ/dt (Eq 8, derived in Methods).