An integrated approach to the characterization of immune repertoires using AIMS: An Automated Immune Molecule Separator
Fig 6
Quantitative comparison of distance metrics used in AIMS and TCRdist.
Both the CDR3-only sequences (A) and the full-CDR sequences (B) of Dash et al. [24] are encoded into AIMS matrices. Sequence distances calculated via TCRdist and AIMS are then directly compared for these CDR3-only sequences (C) or full-CDR sequences (D) for the TCRα- and β-chains. Correlation coefficients between these distance metrics are reported for the full set of sequences and for closely related sequences, which are delineated by the dashed vertical lines.