Information-theoretic analyses of neural data to minimize the effect of researchers’ assumptions in predictive coding studies
Fig 5
Information dynamics of relayed versus non-relayed RGC spikes.
An RGC spike was considered relayed to the LGN if it was followed by an LGN spike with the delay reconstructed during lTE estimation. Relayed spikes were accompanied by higher lAIS than non-relayed spikes. Also, relayed spikes led to high lTE in comparison to non-relayed spikes. A–C Spike-triggered average (STA) for lAIS values (A all RGC spikes, B relayed spikes, and C non-relayed spikes); D Mean lAIS for relayed and non-relayed RGC spikes, for each cell pair. lAIS was higher for relayed (dark blue) than for non-relayed (light blue) RGC spikes (p < 0.001*** for a permutation test with 1000 permutations). E–G STA for lTE values (E all RGC spikes, F relayed spikes, and G non-relayed spikes); H Mean lTE values for relayed and non-relayed RGC spikes, for each cell pair. lTE was higher for relayed (dark red) then for non-relayed (light red) RGC spikes (p < 0.001*** for a permutation test with 1000 permutations). I–K STA of RGC spike trains (I all RGC spikes, J relayed spikes, and K non-relayed spikes). Relayed RGS spikes were more often preceded by a spike than non-relayed spikes. L–N STA of LGN spike trains, aligned with corresponding RGC spike train with respect to the reconstructed delay (L all RGC spikes, M relayed spikes, and N non-relayed spikes). As expected, relayed RGC spikes were always followed by an LGN spike, while this was not generally the case for all spikes.