Pervasive, conserved secondary structure in highly charged protein regions
Fig 6
Rethinking assumptions of disorder in highly charged regions.
a The same set of predictors that have been associated with disordered regions turn out to also be compatible with a fully structured helical region. b Present leading-edge methods for disorder and structure prediction disagree completely and also fail to capture experimental reality. The highly charged region of Rcf1 is alternatively predicted to be near-completely disordered or completely helical; experimentally and biologically, it forms most of the membrane-spanning helices and exposed loops in this dimeric mitochondrial inner membrane protein.