Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels
Fig 9
Model dynamics depends on the degree of cAMP-activation of M channels.
Two-parameter BD with bifurcation parameters (IApp, ΔgM) for gM = 50 mS/cm2, EHCN = −50 mV, gHCN = 23 mS/cm2, and ΔgHCN = 12 mS/cm2 (the default values used throughout the paper, see Table 1). Black and red curves indicate respectively HBs in the control conditions (cAMP = 0) and with raised cAMP (cAMP = 1). The curves in blue and magenta represent, similarly, the PDs (PD1 in Fig 8) in the control and stimulated cases. The combination of IApp and ΔgM where MMOs occur is highlighted with shaded blue (control) and magenta (elevated cAMP) areas.