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Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels

Fig 6

Firing Frequency analyses.

The FF of the 5D model under various pharmacological stimulations at different levels of applied current. The black curve shows FFs for the unstimulated (control) condition. Red, magenta and turquoise curves are associated with GCS21680 (GCS; increased cAMP), XE991 (XE; M channel block), and simultaneous XE991+CGS21680 (XE/CGS) application, respectively.

Fig 6

doi: https://doi.org/10.1371/journal.pcbi.1011559.g006