Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels
Fig 5
M-channel inhibition changes the signature of MMOs in stimulated conditions.
Simulations of the model with raised cAMP in the absence (left, blue) or presence of partial M channel inhibition, as in the experiments with Forskolin (FSK) application in the absence or presence of Linopirdine (Lin) [5], are presented. Note how the grey trace presents more full APs (LAOs) and fewer subthreshold oscillations (SAOs).