Ranking of cell clusters in a single-cell RNA-sequencing analysis framework using prior knowledge
Fig 5
Hypothesis-driven rankings across all 3 datasets.
A. LAM cell-rankings based on drugs (DRUG) and pathway databases (KEGG, GOBP, MSIG, WIKI, REACT). The boxplot shows the individual cell rankings obtained by our methodology. The order of the cells is defined by the average rankings across all six parameters used to generate the final ranking for the annotated cell types in the analysis B. ASD cell-rankings based on drugs and pathway databases (KEGG, GOBP, MSIG). The boxplot shows the individual ranking obtained by our methodology. The order of the cells is defined by the average rankings across the three parameters that attained informative information used to generate the final ranking for the annotated cell types in the analysis. C. COVID-19 cell-rankings based on drugs (DRUG) and pathway databases (KEGG, GOBP, MSIG, WIKI, REACT). The boxplot shows the individual ranking obtained by our methodology. The order of the cells is defined by the average rankings across all six parameters used to generate the final ranking for the annotated cell types in the analysis. Results from the bulk RNA-seq simulation are also shown (boxplots highlighted in red).