Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment
Fig 9
Impact of virtual combination therapies.
Points represent the change in the area under the tumor size vs time curve (AUTC) for each combination of the kres, kang, and kconsumption parameters with respect to the one corresponding to the typical parameter estimates (Table 1). The circle in red corresponds to the reference AUTC value. AUTC was calculated from time 0 to 100 days. Additionally, a tumor volume profile over time for four different parameter combinations is shown on the right side of the figure.