Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment
Fig 3
(A) Single case example of tumor volume observation (dots) fitted with the spline function (dashed line), and with a classical tumor growth dynamic model, in this case Gompertz equation (solid line). (B) Using the spline line of the case example as reference (dotted black line), the difference with the best classical model for each individual (Gompertz equation for this case example) is represented with a solid black line. Additionally, crossing with the zero-line (red points) and the local extrema (blue triangles) are marked in the graph.