XA4C: eXplainable representation learning via Autoencoders revealing Critical genes
Fig 5
Critical genes show distinct co-expression networks in tumor and normal tissues.
The Lysine degradation pathway (I00310) is used. Critical genes (light blue) are located at the core of the network, surrounded by additional genes from the same pathway (gray). The boundaries of Pearson’s correlation coefficients range from +0.8 (red) to -0.8 (blue). Boxplots show the distributions of two sets of correlations (tumor vs. normal) together with the P-value of the Kolmogorov-Smirnov test, with the null hypothesis being that the two samples were chosen from the same distribution. Critical genes shown in this figure are novel as they have not been identified by traditional analysis search for Hub nor DiffEx genes.