Network-neuron interactions underlying sensory responses of layer 5 pyramidal tract neurons in barrel cortex
Fig 5
Reduced models predict contribution of input pathways to sensory responses.
A: Absolute contribution of presynaptic populations to WNI following a PW stimulus to a model located at the center of the C2 column: pyramidal neurons in L2/3 (L2PY, L3PY), spiny neurons in L4 (L4SP), intratelencephalic neurons in L5 (L5IT), L5PT, corticocortical neurons at the L5/6 border (L6CC), and relay cells in the ventral posterior medial nucleus of thalamus (VPM). Despite the lack of sensory-evoked responses by L4PY, L6CT and L6INV [14], their contributions were considered in the overall WNI calculations (Figs 2 and 3). B: Sensory-evoked contribution (i.e. absolute contribution minus baseline for each input pathway) of presynaptic populations to WNI following a PW stimulus. C: Sensory-evoked contribution of presynaptic populations to WNI following a SW stimulus. D: Contribution of the main input pathways–VPM and L6CC–depending on the soma location of the L5PT model in a 9x9 grid across the C2 column for a PW stimulus. The black circle denotes the C2 column border. E: Comparison between model responses to 9 different whisker stimuli (PW and 8 SW) under control conditions and when removing sensory-evoked input from L6CC. Removing evoked L6CC activity attenuates responses, in particular to surround whiskers.