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Controlling brain dynamics: Landscape and transition path for working memory

Fig 5

Connectivities in local circuits underlie working memory performance.

(A) Effects of lesions on individual areas on transition action from spontaneous state to the memory state. The blue dashed line represents no brain lesions. The increase in the transition action for any silenced areas suggests that the formation of distributed working memory becomes harder. The top 10 silenced brain areas which have a strong impact on working memory are consistent with the ‘bowtie hub’ proposed by [33] except LIP. (B) Both the number of attractors and transition action from spontaneous state to memory state increase with increasing maximum recurrent strength (Jmax). (C) Four typical landscapes for increasing Jmax. (D-G) The robustness against random fluctuations as a function of the barrier height of MA (USA), quantifying the network structure. The red dots represent default values.

Fig 5

doi: https://doi.org/10.1371/journal.pcbi.1011446.g005