How robust are estimates of key parameters in standard viral dynamic models?
Fig 8
Heatmap RMSEs calculated with the RCM and different combinations of population parameters.
A) RMSEs for different combinations of literature values. B) RMSEs for fixed infection rates from literature and estimated virus production rates. C) RMSEs for fixed virus production rates from literature and estimated infection rates. ◊ = the population parameters we estimated, x = values for β and/or π found in literature. Parameter values can be found in Table C in S2 Text. Note that the underlying heatmap is the same for A), B), and C), and it was calculated from fits to the post-peak viral load data set and assumed 5 days to reach peak viral load for each pair of β and π values indicated in the x and y-axes, respectively (see S1 Data for RMSE values).