How robust are estimates of key parameters in standard viral dynamic models?
Fig 3
The best RCM fit to viral load measurements of the 25 selected individuals.
Filled circles are measurement points; non-filled circles are censored and below the detection limit (dotted grey line). We fixed population parameters (without allowing random effects) for the initial target cell population, T0 = 8×107 cells, initial eclipse cell population, E0 = 1 cell, transition rate out of the eclipse phase, k = 4 /day, and the virus clearance rate, c = 10 /day (see Table 1 and Table B in S2 Text for individual parameters, S1 Data for viral load measurements and model predictions).