How robust are estimates of key parameters in standard viral dynamic models?
Fig 2
Schematic illustration of the refractory cell model.
A susceptible target cell, T, is infected by virus, V, with the infection rate constant β. Infected cells in the eclipse phase, E, become actively virus-producing cells, I, with the transition rate constant k. Infected cells, I, produce virus with production rate constant π or die with degradation rate δ. Virus is cleared with clearance rate c. In the refractory cell model, in addition we also account for the innate immune response, which turns susceptible cells into refractory cells,R, with constant rate φ, which are in an antiviral state and refractory to infection. However, refractory cells can become susceptible to infection with constant rate ρ. [Created with BioRender.com].