Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load
Fig 2
Described is the process for obtaining 10,000 parameter sets for the mathematical model of N-803 treatment of SIV (Eqs 1–11, Fig 1) that replicate SIV viral load and CD8+ T cell counts from two non-human primate cohorts (Table 3). The left side describes the top-level parameter fitting algorithms. The right side describes the bottom-level calculation of model costs by solving the model from different initial conditions corresponding to each cohort and a shared set of model constants.