Agent-based modeling of nuclear chromosome ensembles identifies determinants of homolog pairing during meiosis
Fig 5
Effects of chromosome size on pairing kinetics and efficiency.
(A) Average distances over time between homolog pairs where repulsive and attractive radii are adjusted proportionally to the sizes of actual yeast chromosomes. Note that the three smallest homolog pairs are markedly slower in achieving pairing than all other chromosomes. (B) Non-homologous chromosomes equidistant to each of the two homologs were identified at t = 3h and their distances were monitored throughout the simulation in the same set of model nuclei monitored in (a). (200 realizations, error bars indicate SD). The gray rectangle highlights pairing distances at or below 400 nm.