Agent-based modeling of nuclear chromosome ensembles identifies determinants of homolog pairing during meiosis
Fig 2
Strength of exponentially decaying forces between non-homologous (short-range repulsive) and homologous (short-range attractive) chromosomes.
Vertical black lines represent the centers of mass, xi, and the colored regions indicate each chromosome’s force modeled as a decaying exponential. The first column shows the strength of the forces. The second column shows a cartoon illustration of the corresponding chromosome dynamics when they meet, and the third column contains representative frames from Supplemental Movie 1 [45]. The solid circles on the righthand side indicate the effective interaction radius (see Table 1) beyond which the force is negligible. (A-C) Illustration of exponentially decaying forces when two non-homologous chromosomes meet. The repulsive force felt by a non-homologous chromosome corresponds to where its center of mass crosses into the other chromosome’s repulsive region (denoted by * in A). (D-F) Similar illustrations but for an attractive homologous interaction.