Simulation-based inference for efficient identification of generative models in computational connectomics
Fig 5
Synapse-level wiring rule inferred with SBI differs from Peters’ rule.
We compared an SBI-inferred parametrized wiring rule predicting synapse counts on the subcellular level with a corresponding formulation of Peters’ rule. (A) SBI posterior for the wiring rule parameter θ (probability of forming a synapse if two neurons are close), compared to Peters’ rule assuming θ = 1 (gray). (B) Number of synapses predicted by the inferred posterior (blue) and Peters’ rule (gray) compared to the number of presynaptic boutons realistically available in the structural model (dashed black), plotted over the entire cortical depth of the barrel cortex column. (C) Connection probabilities simulated from the inferred synapse level posterior (blue) and Peters’ rule (gray) compared to the measured connection probabilities (black).