Simulation-based inference for efficient identification of generative models in computational connectomics
Fig 4
Neuron-level wiring rule inferred with SBI differs from Peters’ rule.
We used SBI to infer a proximity-based wiring rule at different spatial resolutions of the rat barrel cortex model and compared its predictions to that of Peters’ rule. (A) Distributions of the shared subvolumes v between neurons in the barrel cortex model for each spatial resolution (subvolume edge length, see legend in (b)). (B) SBI posteriors inferred over the connection threshold parameter of the wiring rule (θthres, number of shared subvolumes required to form a connection), shown for each spatial resolution (colors), and for Peters’ rule assuming θthres = 1 (gray). (C) Connection probabilities simulated from the inferred posterior (orange) and Peters’ rule (gray) compared to the measured connection probabilities (black).