Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family
Fig 10
Evolutionary histories of hyalectanases PPIs.
(A) Hyalectanase tree. The last common ancestor of the human hyalectanases is the G96 gene node. The gain of the ACAN and VCAN PPIs was inferred at the G96 gene node. (B) Heatmap: the published interactions of H. sapiens hyalectanases with ACAN, VCAN, LRP1, TIMP3 and COMP are represented as dark blue boxes. The PPIs inferred by PastML tool are represented as light blue boxes. At the opposite the absence of interaction (missing information) between hyalectanases and ACAN, VCAN, LRP1, TIMP3 and COMP is represented as dark orange boxes (for human proteins) and the absence of interaction inferred by PastML is represented as light orange boxes (for non human proteins).