Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family
Fig 9
Three module signatures are associated with COMP and/or CCN2 PPIs.
The ancestral module signatures reported on the descendant proteins in H. sapiens: (A) ADAMTS-7, (B) ADAMTS-4 and (C) ADAMTS-3. The location of the modules is represented as green boxes along with the location of the Pfam domain represented as grey boxes (top panel) while the content of the modules is represented by raw sequence logos [49] using the Protomata visualization [14], which displays also the chaining of the modules with arrows labeled by the minimal and maximal distances between the modules in the sequences of descendants (bottom panels). Because of the size of the G161 module signature, only the modules in the region of interaction with COMP are shown in (A).