Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family
Fig 7
Location in H. sapiens paralogs of the modules involved in the 45 events of module(s)-PPI(s) co-appearance.
(A) ADAMTS-TSL phylogeny indicating the 45 ancestral nodes (labels in white boxes) corresponding to the 45 module(s)-PPI(s) co-appearance events. TS, ADAMTS; TSL, ADAMTSL; Hs, Homo sapiens; Dr, Danio rerio; Xt, Xenopus Tropicalis; Gg, Gallus gallus; Mm, Mus musculus; Bt, Boss Taurus. (B) Each line corresponds to a H. sapiens protein chosen as representative of the ancestors, and onto which the ancestral module signature is reported. The Pfam domains are represented as grey boxes and the gained modules as green marks. Each sequence is divided into 3 regions; 1) the N-terminal region that contain the propetide in ADAMTS (blue), 2) the central region including the catalytic domain and the disintegrin domain (orange) and the central TSP1, the cys-rich domain and the spacer (yellow) and 3) the variable ancillary region from the end of the spacer to the C-terminal end (purple).