Flux balance analysis-based metabolic modeling of microbial secondary metabolism: Current status and outlook
Fig 4
Schematic diagram of the combination of metabolic and GRNs to predict the secondary metabolite production.
The stress signal stimulates the expression of RF, resulting in the activation of enzymes catalyzing reactions for secondary metabolite biosynthesis. Orange circle: secondary metabolite; pink circle: primary metabolite. Enz, enzyme; GRN, gene regulatory network; RF, regulatory factor.