Flux balance analysis-based metabolic modeling of microbial secondary metabolism: Current status and outlook
Fig 3
An illustrative example of pH-induced EPS production in lactic acid bacteria, used to explain the constrained proteome allocation model for both primary and secondary metabolism.
(A) The metabolic network of lactic acid bacteria for both primary metabolism (C, R, T sectors) and secondary metabolism (U sector). (B) Simulated metabolic response to pH: the increase of acidity inhibits the growth rate and induces EPS production. (C) Simulated proteome allocation in response to pH: the increase of acidity activates secondary metabolism, and more proteome resources get allocated to the U sector. Note: this “toy” model is for illustration only. EPS, exopolysaccharide.