Identification of Low-Complexity Domains by Compositional Signatures Reveals Class-Specific Frequencies and Functions Across the Domains of Life
Fig 6
Percentage of organisms with significantly enriched LCDs after accounting for amino acid frequencies.
The percentage of organisms with significantly enriched LCD-containing proteins (relative to a scrambled version of each proteome) is depicted for each LCD class in archaea (A), bacteria (B), eukaryota (C), and viruses (D). LCD frequencies in the original and scrambled proteomes were compared using Fisher’s exact test for each LCD class in each organism. Within each organism, p-values for all represented LCD classes (i.e., those with at least one LCD instance in the original or scrambled proteomes) were corrected using the Holm–Šidák correction method to account for multiple hypothesis testing. Significant enrichment is defined as p < 0.05 after multiple-test correction.