Identification of Low-Complexity Domains by Compositional Signatures Reveals Class-Specific Frequencies and Functions Across the Domains of Life
Fig 2
LCD classes most frequently associated with the same function(s) across organisms for each domain of life.
(A) For all GO terms significantly associated with an LCD class in at least one organism, the percentage of organisms sharing significant enrichment for that LCD class/GO term pair was calculated separately for each domain of life. Each dot represents a single LCD class/GO term pair. (B) Top 50 LCD class/GO term pairs with respect to the percentage of organisms sharing significant enrichment for that pair in eukaryotes. (C,D) Top 25 LCD class/GO term pairs with respect to the percentage of organisms sharing significant enrichment for that pair in archaea and bacteria, respectively. For panels B-D, bar color corresponds to LCD class, with reciprocal classes (e.g., GR and RG LCDs) assigned the same color for simplicity. GO terms on the x-axis are colored according to the GO-term category with Biological Process (BP) in red, Cellular Component (CC) in green, and Molecular Function (MF) in blue. Top-ranking LCD class/GO term pairs for viruses are shown in S9 Fig. For simplicity, only GO terms that were significantly enriched (Šidák-corrected p < 0.05) and had a minimum depth of 4 in the gene ontology are shown.