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Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics

Fig 7

Model validation.

Model best fit curves (solid lines) with measured HBV DNA kinetics (circles) in representative mice M5, M6 and M7 inoculated with and 10⁷ (A), 10⁶ (B), and 10⁴ (C) HBV genome equivalents, respectively. Estimated model parameters are shown in Table 1.

doi: https://doi.org/10.1371/journal.pcbi.1011309.g007