Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics
Fig 6
Model parameter estimates for representative mouse M1.
(A and B) Simulated serum viral load. (C and D) The number of total cells in eclipse phase (solid gold line), productively infected cells (solid red line) and the average virion production (or secretion) per productively infected cells (solid green line) per time post inoculation. Graphs are divided according to the kinetic phases of HBV serum DNA amplification observed experimentally in Fig 1. Phases 5 and 6 are graphed separately to accommodate the larger y-axis scale required later in infection. Dashed vertical lines and black-shaded numbers indicating kinetic Phases 1–4 in (A) and (C) and Phases 5 and 6 in (B) and (D).