Pan-cancer characterization of ncRNA synergistic competition uncovers potential carcinogenic biomarkers
Fig 2
The ceRNA regulation landscape across malignant tumors.
(a) The number of ncRNA-related ceRNA interactions in each malignant tumor. (b) The topological characteristics of ncRNA-related ceRNA networks for the 31 malignant tumors. The Degree column is the p-value of fitting power-law distribution. The p-values equal to or more than 0.05 indicate that the degree of ncRNA-related ceRNA networks obeys the power-law distribution. The Path and Density columns represent the–log10(p-value) of Student’s t-test, and the p-values less than 0.05 display that the characteristic path lengths (or densities) of ncRNA-related ceRNA networks are significantly shorter (or higher) than those of their corresponding random networks. (c) The similarity matrix shows the similarity between each pair of lncRNA (upper triangle) and pseudogene (lower triangle) related ceRNA networks across 31 malignant tumors. (d) The radar chart shows the percentage of ceRNA regulations predicted in different numbers of malignant tumors. (e) The conserved ceRNA regulation predicted in 31 malignant tumors.