Effective mechanical potential of cell–cell interaction explains three-dimensional morphologies during early embryogenesis
Fig 8
Simulations under inferred distance–potential curves in drug–treated embryos, and identification of parameters explaining morphological transition.
A. Simulation results for the drug–treated embryos. All simulation data are provided in S15A Fig, and the representative results which nearly showed the mean values of the sphericities for each condition are chosen here. B. Sphericities in the simulations of the drug–treated embryos (left panel), and the sphericities plotted against the distances at the potential minima calculated in Fig 7C. Mann–Whitney–Wilcoxon tests were performed: p–values for “No Drugs” vs. “EDTA”, vs. “CytoD”, and vs. “Bleb” are 0.011, 1.0, and 0.00080, respectively. C. Aspect ratios in simulations of the drug–treated embryos (left panel), and the aspect ratios plotted against the relative distances providing 10% energy of the potential minima calculated in Fig 7C. Mann–Whitney–Wilcoxon tests were performed: p–values for “No Drugs” vs. “EDTA”, vs. “CytoD”, and vs. “Bleb” are 0.21, 0.97, and 0.33, respectively. Related figures: S15 Fig (all simulation outcomes).