Effective mechanical potential of cell–cell interaction explains three-dimensional morphologies during early embryogenesis
Fig 5
Inference of the effective force of cell–cell interaction in mouse pre–implantation embryos.
A. Eight–cell and compaction stages of mouse embryo are illustrated, and their confocal microscopic images are shown: bright field, maximum intensity projection (MIP) and cross–section of fluorescence of H2B–EGFP. Snapshots of nuclear tracking are also shown; blue spheres indicate the detected nuclei. Scale bars = 15μm. B. Inferred DF and DP curves. Related figures: S9 (data from other embryos) and S10 (DF and DP curves in the outer and inner cells in the compaction stage) Figs. Related movies: S3, S4 (tracking data), S5 and S6 (force maps) Movies.