A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites
Fig 9
Repairing neuronal dendrites is likely to improve simulations of NMDA spikes, which are reduced in extended human neurons compared to mice.
A, Mouse CA1 pyramidal cell with basal dendrites in blue. Stimulation and recording sites are indicated on the basal dendrite. Right, Human and human extended morphology with basal dendrites in green and black with the growth volumes indicated by the black dashed lines. The human extended version was created by extending the human reconstuction in A, Middle. (continued) B, Example dendritic NMDA spikes for a mouse (blue), human (black) and human extended (green) morphology at 85.19% of the maximum possible Euclidean distance in the basal tree away from the soma for each morphology, respectively. C, Peak NMDA spike voltage measured for different numbers of synapses at different distances from the soma in the basal dendrite, given as a percentage of the maximum possible distance in the basal tree (colour scheme as in B). For each distance, 10 different locations at that distance were tested (transparent dashed coloured lines). The average is shown as a solid line. The synapses were distributed over 20μm sections. D, Dendritic diameters for the locations described in C, with mean and standard deviation.