A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites
Fig 7
The repair algorithm restores the electrophysiological behaviour of cut and repaired mouse pyramidal cells and allows for better predictions of neuronal function in human neurons.
A, CA1 pyramidal cell of the mouse. Left, Reference morphology, Middle, Repaired morphology with growth volume indicated by the black dashed line. Cut dendritic sections in magenta, repaired dendritic sections in green. Right, Somatic voltage traces induced by current injections in the soma of reference (black), cut (magenta) and repaired (green) morphology with resting membrane potentials (Top) and current clamp increments (Bottom). The inset on the left shows the F-I curves of the data on the right (same colour scheme). B, Human CA1 pyramidal cell. Same arrangement as in A. Repair restores the electrophysiological behaviour of the reference neuron. C, Prediction of the electrophysiological behaviour of an extended human CA1 pyramidal cell. Arrangement as in A but the reference morphology on the left is the full but incomplete reconstruction as provided in Ref. [26], which has been extended using the repair algorithm (c.f. Fig 6).