The σB alternative sigma factor circuit modulates noise to generate different types of pulsing dynamics
Fig 6
Core circuit noise compared to upstream noise.
(A,B) For each combination of core circuit noise amplitude (η) and upstream pathway noise amplitude (ηamp) we vary the parameter pprod (over the interval 20 < pprod < 200) and calculate each behaviour’s distinctness (Section 4.5.3). The total amount of noise in the system, rather than how it is distributed between the core and upstream pathway, is an important determinant for both behaviours’ occurrence. (A) The single pulse response behaviour is distinct when both types of noise are low. (B) The stochastic pulsing behaviours require some amount of noise (in either pathway), but do diminish if the total amount of noise becomes too large. It is especially prominent when core circuit noise amplitude (η) is small and upstream pathway noise amplitude (ηamp) is intermediately valued. Parameter values and other details on simulation conditions for this figure are described in S7 Table.