Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators
Fig 9
The effect of simulator parameters on ventricular systole and atrial diastole.
Barplots of the total order effects of the input parameters, ranked from most to least important, for ventricular peak pressure, ESV and atrial maximum volume during the v-wave. The red and blue bars indicate parameters that explain >90% of the output variance, the gray bars indicate parameters that explain up to 95% of variance, while the rest of parameters are not displayed. Red and blue indicate positive and negative interactions, respectively. When this resulted in more than 10 parameters, the number of parameters was limited to 10 or to the number of parameters explaining 90% of output variance.