Dose optimization of an adjuvanted peptide-based personalized neoantigen melanoma vaccine
Fig 5
Optimal peptide concentrations.
Bar plots correspond to optimal peptide doses as the number of folds of the clinical trial dose for each vaccination using J1 (blue) and J2 (green). The horizontal dashed line represents the dose used in the clinical trial (baseline) given in Table 2 for each patient. The total number of immunizing peptides is also reported at the top of each panel. The weights for J1 are A1 = 1 and B = 1/3, while for J2 the weights are A1 = 1, A2 = 1 and B = 1.