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Dose optimization of an adjuvanted peptide-based personalized neoantigen melanoma vaccine

Fig 3

Optimal peptide dose selection.

Selecting the predicted optimal peptide dose with higher clinical benefit in overall tumor reduction than the tested vaccine dose. Blue and Red curves correspond to J and J_T scores as a function of the predicted optimal doses, . Horizontal lines indicate the J and J_T scores of tested dose, . Red region includes suboptimal doses. Blue region offers doses with potential clinical benefit. Doses below the blue dashed line are optimal with uncertain clinical benefit. Doses between dashed lines are optimal with lower clinical benefit. Doses in the green region are optimal, with a higher benefit in tumor reduction.

doi: https://doi.org/10.1371/journal.pcbi.1011247.g003