Computational model of integrin adhesion elongation under an actin fiber
Fig 5
With high actin bundling, actomyosin tension has no effects on adhesion stabilization.
A. The average fraction of ligand-bound integrins varying Pbundling between 0–1, and Fmyo between 0–30 pN and using k = 0.6 pN/nm. B. The average total ligand-bound time for integrins, varying Pbundling between 0–1, and Fmyo between 0–30 pN and using k = 0.6 pN/nm. Data are computed as averages from three independent simulations. C. The average fraction of ligand-bound integrins for probabilities of actin filaments bundling Pbundling = 0, 0.5, and 1, varying Fmyo between 0–30 pN and k between 0.2–0.6 pN/nm. D. Distribution of the final tension on the integrin-ligand bonds before failure varying Fmyo between 0–30 pN, using Pbundling = 0 and 1, and fixed substrate stiffness at k = 0.6 pN/nm. All data are computed between 100–300 s of simulations, from three independent runs. F. The average angle of integrin adhesions relative to the fiber axis using Pbundling = 0 and 1, using Fmyo = 0 and k between 0.2–0.6 pN/nm. The angle is calculated from the direction of the first principal component considering the 2D positions of ligated integrins, at each second of simulation.