Computational model of integrin adhesion elongation under an actin fiber
Fig 2
Experimental image showing adhesion elongation and stabilization under actin fibers.
COS7 cell, transiently transfected to co-express mScarlet-paxillin and EGFP-F-tractin. A. mScarlet-paxillin imaged by Total Internal Reflection Fluorescence Microscopy (TIRFM) and B. EGFP-F-tractin imaged by epifluorescence. Edge motion is shown in 80s intervals. Nascent adhesions (circles) assemble (orange to red) and disassemble (red to orange) as the leading edge moves forward. Stabilized adhesions under bundled actin fibers (blue arrows) do not disassemble.