Computational model of integrin adhesion elongation under an actin fiber
Fig 1
Computational model of integrin-based adhesion assembly in the presence of an actin bundle.
A. Schematics of the 2D computational model. The domain consists of a grid of ideal springs (gray particles) with stiffness k. Integrins diffuse (green particles) with diffusion coefficient D and establish harmonic interactions with the substrate springs (magenta particles). If integrins are in the region of the actin fiber (pink area) a force, Fmyo is also added. Fmyo build tension on the integrin-ligand bond. This tension determines the bond lifetime, τ, which is the reciprocal of the rupture rate, koff, as τ = koff. B. The bond lifetime versus force relation for integrin-ligand bonds follows catch-slip bond kinetics.