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Filter inference: A scalable nonlinear mixed effects inference approach for snapshot time series data

Fig 7

Computational costs of filter inference and traditional NLME inference I—Evaluation time of log-posterior.

The figure shows the evaluation time of the traditional NLME log-posterior and its gradient, defined in Eq 7, (blue lines) and the filter inference posterior and its gradient, defined in Eq 10, with a Gaussian filter and S = 50, S = 100 and S = 150 simulated individuals (red lines). The left and right panel illustrate the results for the early cancer growth model and the EGF pathway model, respectively.

Fig 7

doi: https://doi.org/10.1371/journal.pcbi.1011135.g007