Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization
Fig 7
Simulated tumor growth and angiogenesis before and during different treatment regimens.
Treatment schedules are detailed in Fig 4) Each top row shows the three-dimensional morphology of the tumor and angiogenic vessels, and the corresponding lower panels show the central cross-section of the tumor in the y-z plane (side view) or x-y plane (top view). Various cell phenotypes are indicated by the contour plot colors: normal tissue around tumor (blue), proliferating cancer cells (green), quiescent cancer cells (orange), and necrotic cancer cells (yellow). The various treatments result in dramatic differences in tumor morphology and viability status.