Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization
Fig 5
Spatial maps of interstitial fluid pressure (IFP, top panels) and anti-cancer drug distribution in the tumor and surrounding tissue (bottom panels).
The gray lines in the anti-cancer drug maps delineate the tumor. Treatment with anti-VEGF decreases vessel permeability, preserving the transvascular pressure that drives blood plasma perfusion and interstitial fluid flow. The drug administration schedules are shown below each panel (blue: Anti-angiogenic (AA) drug; red: cisplatin). Note that the metronomic and anti-VEGF treatments can decrease tumor IFP, and that there are differences in drug exposure to the tumor and normal tissues with the various treatments.