Modeling the impact of xenointoxication in dogs to halt Trypanosoma cruzi transmission
Fig 5
Mathematical models of T. cruzi transmission dynamics between dogs and T. infestans in domestic and sylvatic cycles.
Dashed lines represent transmission events and solid lines represent transition between states. Prior to treatment, only vectorial transmission (blue lines) is considered to transition susceptible dogs (1-X) to infectious (X). Susceptible bugs (1-X) are replenished by a logistic birth rate. After administration of fluralaner, there are two transmission routes to infect susceptible dogs: vectorial transmission as before (blue line) and oral transmission (yellow line). In the sylvatic cycle, vectorial transmission is constant due to exposure to external infectious bugs (MM).