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Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference

Fig 2

HNN model schematic.

A: Local network connections of the HNN model include: 1) excitatory AMPA and NMDA synaptic connections (black circles) originating from pyramidal neurons (blue), and 2) inhibitory GABAA and GABAB synaptic connections (black lines) originating from inhibitory interneurons (yellow). B: Proximal exogenous input connection pattern. C: Distal exogenous input connection pattern, see text for further description. D: 3D rendering of full neocortical column model. Figure adapted from Neymotin et al. 2016 [5].

Fig 2

doi: https://doi.org/10.1371/journal.pcbi.1011108.g002