Folding kinetics of an entangled protein
Fig 4
Time series from refolding trajectories for the RD1 protein.
Upper row: fraction of native contacts Q with labels referring to the visited states. Lower row: entanglement indicator 〈G′〉. (a) Example of “fast” folding trajectory. The two red arrows illustrate how in the folding transition the entanglement indicator reaches native values before the fraction of native contacts does the same, delimiting the short visit to the IE− intermediate prior to folding. In this trajectory, it is shown an example of a visit to IE− followed by a return to the unfolded state. (b) Example of “threading” trajectory. (c) Example of “backtracking” trajectory. The red arrow marks the final folding transition.